How to Assemble a Capsid
نویسندگان
چکیده
Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.
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ورودعنوان ژورنال:
- Cell
دوره 131 شماره
صفحات -
تاریخ انتشار 2007